Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 25;14:2153. doi: 10.1038/s41598-024-52311-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Gene expression comparison between Commercial iMGL cells and microglia-related datasets. (A) Representative immunofluorescence images of Commercial iMGL cells stained with IBA1 or P2Y12 (green) and DAPI (blue). The scale bar represents 20 μm. (B) This study performed bulk and single cell transcriptional profiling of Commercial iMGL cells between 0 and 4 days in culture. (C) PCA clustering using top 2 PCs for Commercial iMGL cell samples and microglia comparator datasets. Variance explained by each principal component is shown in parenthesis. (D) Euclidean distances for all pairs of samples between ex vivo microglia and each of the other microglia groups. Euclidean distances were calculated using sample loadings on PC1 and PC2. (E) Comparison of gene expression levels for key microglia TFs, core marker genes, and disease risk genes between Commercial iMGL cells at Days 1–4 and ex vivo microglia. Expression levels displayed are the median values across samples. (F) Comparison of gene expression levels for HPC and EMP progenitor and monocyte markers between Commercial iMGL cells at Days 1–4, ex vivo microglia, and monocytes. Expression levels displayed are the median values across samples.