TABLE 1.
Kinetics and cell contents of tissue inflammatory reactions in murine candidiasisa
| Candidiasis effect | Result in tissue at postinfection day:
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Kidney
|
Heart
|
Liver
|
Brain
|
|||||||||
| 3 | 14 | 28 | 3 | 14 | 28 | 3 | 14 | 28 | 3 | 14 | 28 | |
| Lesions | ++ | + | +/− | ++ | + | +/− | +/− | ++ | + | − | ++ | +/− |
| Macrophages | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | − | ++ | ++ |
| T cells | +/− | + | +/− | +/− | + | +/− | +/− | + | +/− | − | + | +/− |
| B cells | +/− | + | +/− | +/− | + | +/− | +/− | +/− | +/− | − | − | − |
| Neutrophils | +/− | − | − | +/− | − | − | + | +/− | − | − | − | − |
a
The extension or multiplicity of lesions and the ratio of different inflammatory cells were scored between − (none) and ++ (dominant). Note that Mφ were the dominant cell type at each time of infection, the ratio of lymphocytes was increased at 14 days, and small numbers of neutrophil granulocytes could only be observed at an early stage. Most of the T cells were CD4+, and Mφ became MHC II+ at a later stage of the infection.