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. 2024 Jan 25;15(1):88. doi: 10.1038/s41419-024-06463-6

Fig. 1. Basic information on the FASN gene and protein and the function of FASN.

Fig. 1

a The location of the FASN gene. b Generalized linear domain map of animal FASN. c The basic structure of the human FASN protein 3D structure (http://www.genecards.org). d FASN-mediated biosynthesis pathway of fatty acids. Glucose is phosphorylated to glucose-6P when ingested by cells and enters the glycolysis pathway. The resulting pyruvate enters the mitochondria and is converted to acetyl-CoA before entering the citric acid cycle. The citrate then travels through the mitochondria and is converted to acetyl-CoA by the ACL. Then, acetyl-CoA is converted to malonyl CoA. Using NADPH as a reduction cofactor, FASN catalyzes the synthesis of acetyl-CoA and malonyl-CoA palmitate and then synthesizes complex fatty acid metabolites. TCA tricarboxylic acid cycle, NADPH nicotinamide adenine dinucleotide phosphate hydrogen.