Fig. 1.

Schematic diagram of Mut p53 blocking anti-tumor immune response. Mut p53 down-regulates the expression of Tap1 and Erap1, which are necessary for MHC-I to be transported to the cell surface. The expression of MHC-I on the cell surface decreases and MHC-antigen complex decreases, which can not be recognized by T cells and finally blocks the anti-tumor adaptive immune response. On the other hand, Mut p53 inhibits TBK1 phosphorylation by binding with TBK1, thus inhibiting the function of cGAS-STING-TBK1-IRF3 pathway, which is a cytoplasmic DNA sensing mechanism in natural immune response, and reducing the infiltration of NK cells, CD8⁺T cells and other lymphocytes in TME, leading to tumor immune escape