Figure 1.

Maqui extract rich in Delphinidin prevent weight loss, improve clinical outcomes and macroscopic parameters in experimental animal model of Crohn’s disease-like colitis induced by TNBS. (A) Distribution of polyphenolic compounds in maqui extract as determined by (UHPLC-MS/MS) Orbitrap. The data are expressed as a proportion of polyphenol content. The effect of orogastric maqui extract on (B) DAI score recorded throughout the entire experiment, (C) Percent body weight loss in mice over the experiment and until sacrifice (28), (D) Percent body weight at day 5 (culling day), (E) Colon weight as percent of body weight on day 5 (F) Representative macroscopic image from the entire intact colon isolated from CD group (a,b,c), Control group (d), post- and pre-Treatment groups (f) and Supplementary Figure S1 . Values represent mean ± SEM (n=6). p-value < 0.05, p-value < 0.001 and p-value < 0.0001; one-way ANOVA followed by Bonferroni’s Multiple Comparison test are shown between different experimental groups.