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. 2024 Jan 12;14:1229767. doi: 10.3389/fimmu.2023.1229767

Figure 6.

Figure 6

Impact of Maqui extract rich in anthocyanins on PPAR-α expression in colon tissue from experimental animal model of Crohn’s disease-like colitis. Immuno‐histochemistry analyses for PPAR-α in epithelial cells from colons of each group (n= 6 mice/group): Positive PPAR-α staining in colon epithelium (black arrow) and crypts cells (dashed arrow) in (A) control group, (B) CD group, (C) post-Treatment and (D) pre-Treatment groups. Immuno‐histochemistry analyses for PPAR-α in macrophages cells from colons tissue from 10 representative fields of view for each group: Immune+-PPAR-α staining intensity (black arrow) in (F) control group, (G) CD group, (H) post-Treatment group and (I) pre-Treatment group, (E) Immune positive score (1= <25%; 2 = 25−50%; 3= >50%) for PPAR−α expression in epithelial cells. (J) Counting cells across 10 fields (400x magnification) for PPAR−α expression in macrophages cells. Values represent mean ± SEM; *Difference at the p < 0.0005 level; Kruskal–Wallis test.