. 2024 Jan 12;80:12098. doi: 10.3389/bjbs.2023.12098

TABLE 2.

Relative abundance of the vaginal microbiome in various reproductive conditions.

Reproductive condition	Author (Year)	Genital microbiome relative abundance (%)
Reproductive condition	Author (Year)	Actinobacteria	Bacteroidetes	Candidatus Saccharibacteria	Cyanobacteria	Firmicutes	Fusobacteria	Proteobacteria	Tenericutes	Verrucomicrobia
Tubal pregnancy	Ruan (2021) [47]	Gardnerella 12	Prevotella 6			Lactobacillus 62	Sneathia 3
Tubal pregnancy	Ruan (2021) [47]	Atopobium 4				Megasphaera 2
Chronic endometritis	Lozano (2021) [48]		Prevotella 0.98			Lactobacillus 87.44		Escherichia 0.17
						Streptococcus 9.44
						Dialister 0.68
						Veillonella 0.68
Chlamydia trachomatis	Ceccarani (2019) [34]	Gardnerella 3.65	Prevotella 1.6			Lactobacillus 67.45	Sneathia 0.41	Escherichia 0.33		Akkermansia 0.39
		Atopobium 1	Bacteroides 0.91			Roseburia 4.42		Haemophilus 0.1
		Bifidobacterium 0.46				Megasphaera 2.97
		Coriobacteriaceae, unclassified ^a 0.19				Faecalibacterium 2.31
		Coriobacteriaceae, unclassified ^a 0.19				Ruminococcaceae ^a 1.95
						Clostridiales, unclassified ^a 1.56
						Ruminococcaceae, unclassified ^a 1.03
						Blautia 0.91
						Coprococcus 0.66
						Clostridium 0.65
						Lachnospiraceae, unclassified ^a 0.59
						Ruminococcus 0.58
						Dialister 0.56
						Oscillospira 0.56
						Shuttleworthia 0.54
						Streptococcus 0.49
						Aerococcus 0.24
						Peptoniphilus 0.15
Vulvovaginal candidiasis	Ceccarani (2019) [34]	Gardnerella 7.68	Prevotella 3.76			Lactobacillus 56.69	Sneathia 0.53	Haemophilus 1.42	Ureaplasma 0.41	Akkermansia 0.35
		Atopobium 1.94	Bacteroides 0.81			Roseburia 3.51		Escherichia 0.4
		Bifidobacterium 1.28				Faecalibacterium 2.14
		Alloscardovia 0.57				Ruminococcaceae ^a 1.86
		Coriobacteriaceae,				Aerococcus 1.5
		unclassified ^a 0.24				Clostridiales, unclassified ^a 1.44
						Megasphaera 1.04
						Streptococcus 1.04
						Ruminococcaceae, unclassified ^a 1.02
						Dialister 0.78
						Blautia 0.77
						Coprococcus 0.63
						Ruminococcus 0.59
						Lachnospiraceae, unclassified ^a 0.54
						Oscillospira 0.53
						Gemellaceae, unclassified ^a 0.49
						Veillonella 0.46
						Anaerococcus 0.46
						Finegoldia 0.45
						Gemella 0.37
						Clostridium 0.32
						Shuttleworthia 0.31
						Parvimonas 0.17
						Peptoniphilus 0.13
LR-HPV Infection	Zhou (2019) [39]	Gardnerella 10.83	Prevotella 4.17			Lactobacillus 49.95	Sneathia 5.69	Pseudomonas 1.57
		Atopobium 4.62	Bacteroides 1.89			Saccharofermentans 1.33	Fusobacterium 0.66	Hydrogenophilus 0.55
		Bifidobacterium 2.43				Megasphaera 1.12		Burkholderia 0.48
		Corynebacterium 1.33				Peptostreptococcus 0.62		Escherichia/Shigella 0.30
						Stenotrophomonas 0.57
						Dialister 0.42
						Aerococcus 0.27
						Anaerococcus 0.25
Bacterial vaginosis	Ceccarani (2019) [34]	Gardnerella 11.44	Prevotella 9.15	Rs-045, unclassified ^a 0.43		Lactobacillus 18.8	Sneathia 7.76	Escherichia 0.23		Akkermansia 0.32
		Atopobium 4.92	Bacteroides 0.86			Megasphaera 8.64
		Coriobacteriaceae, unclassified ^a 0.89	Porphyromonas 0.73			Shuttleworthia 7.48
		Mobiluncus 0.49				Roseburia 3.51
		Bifidobacterium 0.33				Clostridium 2.14
						Faecalibacterium 2.09
						Aerococcus 2.06
						Dialister 2.02
						Ruminococcaceae ^a 1.81
						Clostridiales, unclassified ^a 1.58
						Parvimonas 1.39
						Peptoniphilus 1.09
						Ruminococcaceae, unclassified ^a 1.03
						Blautia 0.74
						Peptostreptococcus 0.63
						Coprococcus 0.59
						Oscillospira 0.58
						Ruminococcus 0.56
						Streptococcus 0.54
						Lachnospiraceae, unclassified ^a 0.52
						Anaerococcus 0.39
						Gemella 0.27
						Finegoldia 0.16
Bacterial vaginosis	Hong (2016) [28]	Atopobium 4.46	Prevotella 27.80			Lactobacillus 38.98	Sneathia 7.48	Diaphorobacter 1.67	Mycoplasma 0.35
		Gardnerella 1.36	Porphyromonas 1.29			Aerococcus 5.62	Fusobacterium 0.30	Cupriavidus 1.03
		Mobiluncus 0.69				Megasphaera 1.72
		Coriobacteriaceae, unclassified ^a 0.38				Dialister 1.05
		Coriobacteriaceae, unclassified ^a 0.38				Saccharofermentans 0.94
						Peptoniphilus 0.69
						Anaerococcus 0.55
						Moryella 0.35
Vaginosis	Campisciano (2017) [29]	Actinobacteria ^a 16	Bacteroidia ^a 5			Bacilli ^a 71	Fusobacteria ^a 1	Gammaproteobacteria ^a 4	Tenericutes ^a 1
Vaginosis	Campisciano (2017) [29]		Bacteroidia ^a 5			Clostridia ^a 1		Gammaproteobacteria ^a 4
Aerobic vaginitis	Wang (2019) [41]	Gardnerella	Prevotella			Lactobacillus 41.6	Sneathia	Klebsiella 0.5	Ureaplasma 0.3
		Atopobium				Streptococcus		Escherichia	Mycoplasma 0.12
		Bifidobacterium				Aerococcus
		Alloscardovia				Anaerococcus
						Eubacterium
						Veillonella
						Megasphaera
						Dialister
Empty-sac miscarriage	Liu (2021) [49]		Bacteroides			Lactobacillus		Halomonas
Missed miscarriage	Liu (2021) [49]		Bacteroides		Cyanobacteria ^a	Lactobacillus	Fusobacterium	Halomonas
						Lachnospiraceae ^a		Escherichia/Shigella
						Bacillus		Succinivibrio
						Staphylococcus		Burkhoderia
								Acetobacter
Embryonic miscarriage	Xu (2020) [50]	Bifidobacterium	Bacteroides			Lactobacillus		Escherichia-Shigella
		Gardnerella	Parabacteroides			Faecalibacterium
			Alistipes			Lachnospiraceae ^a
						Roseburia
ART failure	Bernabeu (2019) [51]	Gardnerella				Lactobacillus			Ureaplasma
						Streptococcus
						Clostridium
IUI failure	Amato (2020) [46]	Bifidobacteriaceae ^a 12				Lactobacillaceae ^a 83
IVF failure	Kong (2020) [52]	Gardnerella 7.24	Prevotella 3.02			Lactobacillus 63.09	Sneathia 3.75	Proteobacteria ^a 8.01
		Atopobium 4.14				Streptococcus
						Megasphaera
						Aerococcus
Infertility	Riganelli (2020) [53]	Bifidobacterium	Prevotella			Lactobacillus		Escherichia
		Gardnerella				Streptococcus
		Atopobium				Shuttleworthia
	Zhao (2020) [44]	Bifidobacterium	Prevotella			Lactobacillus
	Zhao (2020) [44]	Atopobium				Aerococcus
Idiopathic infertility	Campisciano (2017) [29]	Actinobacteria ^a 8	Bacteroidia ^a 1			Bacilli ^a 84		Gammaproteobacteria ^a 3	Tenericutes ^a 2
Idiopathic infertility	Campisciano (2017) [29]					Clostridia ^a 1
Diagnosed infertility	Campisciano (2017) [29]	Actinobacteria ^a 5				Bacilli ^a 71		Gammaproteobacteria ^a 23
Diagnosed infertility	Campisciano (2017) [29]					Clostridia ^a 1
Deep endometriosis	Hernandes (2020) [54]	Gardnerella	Prevotella			Lactobacillus		Pseudomonas	Ureaplasma
		Corynebacterium				Streptococcus		Alishewanella
						Enterococcus
						Anaerococcus
PCOS	Hong (2021) [55]	Gardnerella 10.4	Prevotella 7.94			Lactobacillus 58.52	Sneathia 1.57	Mycoplasma 1.25
		Atopobium 4.36				Streptococcus 2.76
		Bifidobacterium 1.55				Megasphaera 1.54
	Tu (2020) [25]	Gardnerella	Prevotella			Lactobacillus	Sneathia	Escherichia-Shigella	Ureaplasma
		Atopobium	Porphyromonas			Streptococcus	Fusobacterium	Campylobacter	Mycoplasma
		Bifidobacterium				Aerococcus		Acinetobacter
		Corynebacterium				Dialister
		Lawsonella				Peptoniphilus
						Finegoldia
						Anaerococcus
						Veillonella
						Megasphaera
						Peptostreptococcus
						Varibaculum
						Staphylococcus
						Ezakiella
Intrauterine adhesion	Liu (2019) [37]	Actinobacteria ^a 24.37	Bacteroidetes ^a 8.64			Firmicutes ^a 61.84		Proteobacteria ^a 2.74

^{^a}

Unknown genera.