Table 3.
Cycle characteristics.
| Characteristic | Group A Letrozole 2.5 mg + FSH |
Group B Letrozole 5 mg + FSH |
P-value |
|---|---|---|---|
| Intervention cycle analysis | n=221 | n=247 | |
| Ovulation rate | 217/221(98.2%) | 239/247(96.8%) | 0.329 |
| Cancellation rate | 6/221(2.7%) | 8/247(3.2%) | 0.740 |
| Ovulate prematurely | 2/221(0.9%) | 0/247(0%) | 0.222 a |
| Follicular dysplasia | 2/221(0.9%) | 3/247(1.2%) | >0.1 a |
| OHSS | 0/221(0%) | 1/247(0.4%) | >0.1 a |
| Reproductive outcomes overall | |||
| Biochemical pregnancy | 90/221(40.7%) | 70/247(28.3%) | 0.005 |
| Clinical pregnancy | 80/221(36.2%) | 65/247(26.3%) | 0.021 |
| Singleton pregnancy | 60/80(75%) | 46/65(70.8%) | 0.568 |
| Multiple pregnancy | 10/80(12.5%) | 14/65(21.5%) | 0.145 |
| Early abortion | 9/80(11.3%) | 4/65(6.2%) | 0.285 |
| Ectopic pregnancy | 1/80(1.3%) | 1/65(1.5%) | >0.1 a |
| Complete data analysis | n=209 | n=231 | |
| Days of uFSH treatment | 4.47 ± 0.15 | 4.51 ± 0.14 | 0.852 |
| One mature follicle | 169/209(80.9%) | 149/231(64.5%) | <0.01 |
| Ovulation with one follicle | 152/209(72.7%) | 154/231(66.7%) | 0.168 |
| Days required for follicles to mature | 13.3 ± 0.16 | 13.12 ± 0.14 | 0.373 |
| Days required for follicles to ovulation | 15.51 ± 0.16 | 15.27 ± 0.15 | 0.202 |
| Hormone concentration on HCG injection day | |||
| LH, IU/L | 10.14(7.54~14.35) | 8.86(6.35~13.1) | 0.014 |
| Oestradiol, pg/ml | 228(156.35~355) | 188.5(120.55~302.5) | 0.001 |
| Progesterone, ng/ml | 0.23(0.1~0.38) | 0.26(0.16~0.49) | 0.011 |
| Endometrial thickness, mm | |||
| HCG injection day | 9.16 ± 0.14 | 9.36 ± 0.15 | 0.367 |
| Ovulation day | 10.16 ± 0.14 | 10.67 ± 0.15 | 0.015 |
a
P-values were calculated using Fisher’s exact test. Values are showed as n (%) or median (interquartile range). When the medians are equal, values are showed as mean ± SD.