Table 2. Sex Differences.
Demographic and imaging biomarker comparisons between EOAD, EOnonAD, and CN cohorts split by sex. Whole FBB SUVR = global amyloid uptake; FTP MetaROI SUVR, Braak 12, Braak 34, Braak 56 = tau uptake.
| EOAD | EOnonAD | CN | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Males | Females | p-value | Males | Females | p-value | Males | Females | p-value | |
| N | 105 | 125 | 45 | 25 | 25 | 52 | |||
| Age, years, mean (SD) | 59.1 (4.3) |
59.2 (4.1) |
0.9 | 58.3 (5.8) |
58.4 (6.8) |
0.9 | 55.6 (6.6) | 56.9 (5.8) |
0.4 |
| Education, years, mean (SD) | 15.3 (2.2) | 15.7 (2.5) |
0.2 | 15.9 (2.7) |
15.0 (2.1) |
0.1 | 17.4 (2.3) | 16.3 (2.1) |
0.04 |
| MMSE (SD) | 22.0 (5.4) | 21.3 (5.0) |
0.3 | 26.4 (2.4) |
24.0 (6.0) |
0.02 | 29.4 (0.7) | 29.3 (0.8) |
0.6 |
| Race, % White | 93% | 95% | 0.01 | 84% | 96% | 0.6 | 76% | 75% | 0.4 |
| APOE-ε4+ (%) | 57% | 51% | 0.4 | 40% | 46% | 0.6 | 33% | 48% | 0.2 |
| Whole FBB SUVR, mean, (SD) | 1.53 (0.2) | 1.61 (0.1) |
<0.001 | 1.00 (0.06) |
1.02 (0.07) |
0.3 | 1.03 (0.1) | 1.03 (0.06) | 0.8 |
| FTP MetaROI SUVR, mean (SD) | 2.00 (0.5) | 2.20 (0.4) |
<0.001 | 1.19 (0.2) |
1.27 (0.4) |
0.3 | 1.20 (0.2) | 1.14 (0.05) |
0.1 |
| BRAAK 12 SUVR, mean (SD) | 1.51 (0.2) | 1.56 (0.2) |
0.1 | 1.17 (0.1) |
1.19 (0.2) |
0.6 | 1.20 (0.2) | 1.14 (0.08) |
0.03 |
| BRAAK 34 SUVR, mean (SD) | 1.80 (0.4) | 1.95 (0.4) |
0.002 | 1.15 (0.2) |
1.21 (0.3) |
0.3 | 1.16 (0.2) | 1.11 (0.05) |
0.08 |
| BRAAK56 SUVR, mean (SD) | 1.75 (0.4) | 1.91 (0.4) |
0.006 | 1.07 (0.2) |
1.14 (0.3) |
0.2 | 1.08 (0.08) |
1.08 (0.05) |
0.8 |
| Hippocampal Vol, cm3, mean (SD) | 2.29 (0.3) | 2.39 (0.3) |
0.01 | 2.48 (0.4) |
2.64 (0.3) |
0.09 | 2.79 (0.3) | 2.77 (0.2) |
0.8 |