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Microglia and neuron interactions in the spinal cord. (A) Schematic of spinal cord and dorsal root ganglia (DRG). (B and C) Microglia-neuron interactions through C1q-C1qR and C3 and C3R pairs. Note that CD47 is an inhibitory signal. (D) Interaction of microglia-death protein (PD)-1 receptor with axonal PD-L1 ligand from DRG neuron. Also see the role of the PD-L1/PD-1 axis in neurological diseases [153].
