Table 1.

Characteristics of each study included

ID	Study/year	Study design	Sample size	Sample mean age (years ± SD)	Sex (F/M)
A1	Carhart-Harris et al., 2021 [34]	Randomised	n = 30 treatment group	43.3 ± 11.7	11/19
A2	Davis et al., 2021 [35]	Randomised	n = 13 treatment group	43.6 ± 13.0	9/4
A3	Carhart-Harris et al., 2016 [33]	Open-label trial	n = 12	42.7 ± 10.2	6/6
A4	Lyons et al., 2018 [37]	Open-label trial	n = 15 treatment group	45.4 ± 2.9	4/11
A5	Carhart-Harris et al., 2017 [23]	Open-label trial	n = 16	42.8 ± 10.1	4/12
A6.a	Goodwin et al., 2022 [36]	Randomised	n = 79 (group A)	40.2 ± 12.2	44/79
A6.b			n = 75 (group B)	40.6 ± 12.8	41/75
A6.c			n = 79 (group C)	38.7 ± 11.7	36/79

SD, standard deviation; F, female; M, male.