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Kaplan-Meier plot and log-rank test showing 15-year BC-specific survival in 1154 patients with IC. In situ cancers (n = 75) were excluded. Patients have been stratified into carriers (orange line) and noncarriers (blue line) of protein-truncating variants (PTVs) in any of the 5 major genes for BC (BRCA1, BRCA2, PALB2, ATM, and CHEK2).
