Table 3.
Clinical and demographic characteristics of the study population overall, and when stratified by presence or absence of CTNNB1 mutation.
| Characteristic | Overall (n=253) | CTNNB1 wildtype (n = 208) | CTNNB1 mutant (n = 45) | P-value |
|---|---|---|---|---|
|
| ||||
| Mean age at diagnosis in years (SD) | 59.8 (12.5) | 61.3 (11.9) | 52.5 (12.5) | < 0.001 |
|
| ||||
| Mean tumor size in cm (SD) a | 4.3 (2.5) | 4.3 (2.5) | 4.0 (2.6) | 0.92 |
|
| ||||
| Histology, n (%) | 0.10 | |||
| Endometrioid | 210 (83%) | 168 (81%) | 42 (93%) | |
| Mixed | 31 (12%) | 28 (13%) | 3 (7%) | |
| Non-endometrioid | 12 (5%) | 12 (6%) | 0 (0%) | |
|
| ||||
| Histologic grade, n (%) b | < 0.001 | |||
| Grade 1 | 37 (15%) | 23 (11%) | 14 (31%) | |
| Grade 2 | 151 (60%) | 124 (60%) | 27 (60%) | |
| Grade 3 | 63 (25%) | 59 (29%) | 4 (9%) | |
|
| ||||
| Deep (≥50%) myometrial invasion, n (%) c | 53 (21%) | 43 (21%) | 10 (23%) | 0.79 |
|
| ||||
| Lymphatic/vascular space invasion, n (%) d | 79 (32%) | 70 (34%) | 9 (21%) | 0.09 |
a
Tumor size data missing for n=13 patients
b
Histologic grade data missing for n=2 patients
c
Depth of myometrial invasion data missing for n=3 patients
d
Lymphatic/vascular space invasion data missing for n=6 patients
SD, standard deviation.