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. 2024 Jan 26;24:19. doi: 10.1186/s40644-024-00658-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Comparison of ^99mTc-MDP bone scintigraphy (A), ⁶⁸Ga-RM26 PET/CT (B), and ⁶⁸Ga-BBN PET/CT (C) in a 73-y-old man diagnosed as having PC (white arrow) with lymph node involvement (red arrow) and bone metastasis (yellow arrow) before prostatectomy. ⁶⁸Ga-RM26 PET/CT detected primary tumors, multiple lymph node involvement, and bone metastasis lesion, whereas those lesions did not significantly show up on ^99mTc-MDP bone scintigraphy and showed extremely mild uptake on ⁶⁸ Ga-BBN PET/CT. This study was originally published in JNM. Zhang, J., et al., PET Using a GRPR Antagonist (68)Ga-RM26 in Healthy Volunteers and Prostate Cancer Patients. J Nucl Med, 2018. 59(6): p. 922–928. © SNMMI