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. 2024 Jan 26;24:19. doi: 10.1186/s40644-024-00658-y
Name Sequence Binding affinity & binding capacity Human study Ref
BBN pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 IC50 = 1.36 nM (BBN), 1.8 ± 0.2 nM ([Tyr4]BBN), 3.3 ± 0.4 nM ([Lys3]-BBN), 20.8 ± 0.3(Aca-BBN(7–14)) No [5658]
AMBA Gly-4-aminobenzoyl-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 Kd = 0.7 ± 0.1 nM (111In-DOTA-AMBA) No [62, 88]
RM1 Gly-4-aminobenzoyl-H–D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 IC50 = 14 ± 3.4 nM ( natIn-DOTA-RM1) Kd = 2.4 ± 0.2 nM (111In-DOTA-RM1) No [62, 88]
RM2 4-amino-1-carboxymethylpiperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 IC50 = 7.7 ± 3.3 nM (RM2), 9.3 ± 3.3 nM (natIn-DOTA-RM2), Kd = 2.9 ± 0.4 nM (111In-DOTA-RM2) Yes [63, 88]
RM26 D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 IC50 = 5.5 ± 0.4 nM (natCo-NOTA-PEG3-RM26) Yes [70, 88]
JMV5132 MPAA-βAla-βAla-[H–D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2] IC50 = 6.8 nM (JMV5132), 3.0 nM (natGa-NODA-JMV5132), 10.0 nM (AlnatF-NODA-JMV5132) No [67]
JMV4168 βAla-βAla-[H–D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2] IC50 = 13.2 nM (JMV4168), 3.2 nM (natGa-DOTA-JMV4168) No [67]
JMV594 H–D-Phe-Gln-Trp-Ala-Val-GlyHis-Sta-Leu-NH2 IC50 = 2.2 ± 0.1 nM (JMV594) No [66]
SB3 p-aminomethylaniline-diglycolicacid-D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-NHEt IC50 = 4.6 ± 0.5 nM (SB3), 1.5 ± 0.3 nM (natGa-DOTA-SB3) No [69, 88]