Empiric antimicrobial treatment of TSS [1,60]. TSS: toxic shock syndrome; m-TSS: menstrual TSS; nm-TSS: nonmenstrual TSS; NSTI: necrotizing soft tissue infection; MRSA: methicillin-resistant Staphylococcus aureus; ESBL: extended spectrum beta lactamase. 1 High incidence of community-acquired MRSA, known carriage, household contamination, previous antibiotic therapy, recent hospital stay, and recent trip in a zone at risk. 2 Previous antibiotic treatment in the last 6 months, travel in endemic area in the last 6 months, known carriage of ESBL strain, hospital stay in the last 3 months, and long institution stay.