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. 2024 Jan 13;13(1):76. doi: 10.3390/antibiotics13010076

Table 6.

Different organic acids used for the control of Salmonella infection in humans and animals.

Plant Major Components Salmonella Serotype MIC Activity References
Thymus vulgaris Thymol (37.5%), p-cymene (14.49%), γ-terpinene (11.15%), linalool (4.71%), and carvacrol (4.62%) S. Typhimurium ATCC 14028 0.25% v/v The zone of inhibition in the agar-well diffusion assay was found to be 25.5 mm against S. Typhimurium, with complete clearance of the bacteria at MIC 0.25% v/v [484]
Origanum vulgare Thymol- and carvacrol-based EO S. enteritidis ATCC 13076 120 μg/mL (carvacrol), 130 μg/mL (Thymol) Complete clearance of the bacteria at 120 μg/mL (carvacrol) and 130 μg/mL (Thymol) in vitro [485]
Pistacia atlantica subsp. Kurdica α-Pinene (10.8%) S. Typhimurium ATCC 14028 0.26 mg/mL Complete clearance of S. Typhimurium was found to be at 0.5 mL/mL with a zone of inhibition of 22 mm [486]
Cinnamomum verum Not identified S. enteritidis,
S. Typhimurium,
S. Heidelberg
>20 μL/mL The zone of inhibition of all of the strains was found to be higher than 20 mm on agar well diffusion assay. [487]
Citrus medica L. Var. Sarcodactylis d-Limonene
terpinene
S. Typhimurium 2.0 mg/mL The zone of inhibition was found to be 20 mm and the inhibition of biofilm formation was found to be 90%. [58]
Ocimum basilicum linalool, 1,8-cineole, eugenol, α-terpineol, ρ-cymene, and germacrene D S. Enteritidis 20 μg/mL Two log reduction in the number of Salmonella when used in food products, colonization resistance was evident [488]
Allium sativum
(Garlic)
diallyl disulfide S. Typhimurium MIC/8 (1/512) μg/mL Inhibition of biofilm formation by 23%, downregulation of virulence genes including invA and sdiA genes [489]
Commercially available Essential oils. Thymol, carvacrol, cinnamaldehyde S. Enteritidis 4.6 mg/mL Complete clearance of illeal and cecal Salmonella in broiler chicken at 10 dpi, improved illeal integrity, gut immunity modulation [33]
Aniba rosaeodora Linaloo S. Typhimurium
S. Pullorum
4 mg/mL
8 mg/mL
In vitro: complete clearance of the bacteria at 4 mg/mL and 8 mg/mL, respectively
In vivo: complete clearance and systemic protection in chicks, modulate host inflammatory process
[490]
Cymbopogon citrates (Lemongrass) Neral, Citral, Geranyl acetate S. Newport --- Significant reduction in bacterial population by 1 log CFU/g when co-cultured with S. Newport [491]