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Invasion and replication in HeLa cells are not affected in ompR mutants. This time course replication experiment shows that the ompR mutants (ARD3 and CJD359) are able to replicate as well as, if not better than, wild-type SL1344. Values are mean numbers of CFU recovered from three wells of HeLa cells (5 × 104 cells each) infected with S. typhimurium at 1, 2, 4, 6, and 8 h postinvasion. This graph depicts results from one of three representative experiments.
