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Comparison of 4 years of the study. White bars, isolates resistant to penicillin; light gray bars, isolates intermediately resistant to penicillin; dark gray bars, isolates susceptible to penicillin but resistant to other antimicrobial agents; black bars, isolates susceptible to all antimicrobial agents tested. The total number of pneumococci was 277, 354, 465, and 591 in the four consecutive years, respectively.
