TABLE 1.
Mutations in an 81-bp region of the rpoB gene in 162 M. tuberculosis MDR isolates
| Mutated codon | Specific mutation | Amino acid change | No. of strains | Frequency 4 (%) |
|---|---|---|---|---|
| 508 | ACC→ATC | Thr→Ile | 1 | 0.6 |
| 513 | CAA→CCA | Gln→Pro | 5 | 3.1 |
| CAA→AAA | Gln→Lys | 2 | 1.2 | |
| CAA→CCG | Gln→Pro | 1 | 0.6 | |
| 515 | ATG→GTG | Met→Val | 1 | 0.6 |
| 516 | GAC→TAC | Asp→Tyr | 5 | 3.1 |
| GAC→GTC | Asp→Val | 4 | 2.5 | |
| GAC→GGC | Asp→Gly | 2 | 1.2 | |
| GAC→GCC | Asp→Ala | 1 | 0.6 | |
| GAC→TTC | Asp→Phe | 1 | 0.6 | |
| GAC→GAG | Asp→Glu | 1 | 0.6 | |
| 517 | CAG→CCG | Gln→Pro | 1 | 0.6 |
| 522 | TCG→TTG | Ser→Leu | 2 | 1.2 |
| TCG→TGG | Ser→Trp | 1 | 0.6 | |
| TCG→TTC | Ser→Phe | 1 | 0.6 | |
| 526 | CAC→TAC | His→Tyr | 14 | 8.6 |
| CAC→GAC | His→Asp | 5 | 3.1 | |
| CAC→CTC | His→Leu | 5 | 3.1 | |
| CAC→CGC | His→Arg | 3 | 1.9 | |
| CAC→TGC | His→Cys | 2 | 1.2 | |
| CAC→AAC | His→Asn | 1 | 0.6 | |
| CAC→ACC | His→Thr | 1 | 0.6 | |
| CAC→CGA | His→Arg | 1 | 0.6 | |
| CAC→GGC | His→Gly | 1 | 0.6 | |
| 531 | TCG→TTG | Ser→Leu | 75 | 46.3 |
| TCG→TGG | Ser→Trp | 2 | 1.2 | |
| TCG→CAG | Ser→Gln | 1 | 0.6 | |
| TCG→GTG | Ser→Val | 1 | 0.6 | |
| TCG→GGG | Ser→Gly | 1 | 0.6 | |
| 533 | CTG→CCG | Ser→Pro | 6 | 3.7 |
| 509-511 | DELETION | 1 | 0.6 | |
| 513-514 | INSERTION | TTC (Phe) | 4 | 2.5 |
a
The mutated codons with corresponding amino acids are indicated. New alleles were indicated in boldface characters.