TABLE 2.
Frequency of codon mutations in RMP-resistant M. tuberculosis isolates from different geographic regionsa
| Country (reference; no. of isolates) | Frequency (%) of mutated codon:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 533 | 531 | 526 | 522 | 516 | 513 | 511 | 508 | No mutation within hot-spot region | |
| United States (26; n = 61) | 8.2 | ||||||||
| Greece (13; n = 17) | 52.9 | 17.6 | 12.0 | 5.9 | 5.9 | ||||
| Asia (8; n = 90) | 53.3 | 16.7 | 1.1 | 14.0 | 5.6 | 1.1 | 6.5 | ||
| Australia (29; n = 33) | 30.3 | 6.1 | 9.1 | 3.0 | |||||
| Italy (18; n = 37) | 2.7 | 59.4 | 35.1 | 8.1 | 2.7 | 0.0 | |||
| Brazil (24; n = 82) | 1.2 | 55.7 | 23.2 | 2.4 | 7.4 | 1.2 | 1.2 | 3.6 | |
| Hungary (2; n = 29) | 31.0 | 6.9 | 38.0 | 6.8 | 10.3 | ||||
| India (12; n = 44) | 2.2 | 63.6 | 22.7 | 4.5 | 2.2 | 6.8 | 2.2 | 2.3 | |
| Spain (6; n = 50) | 2.0 | 48.0 | 22.0 | 14.0 | 2.0 | 6.0 | 0.0 | ||
| East Asia (19; n = 66) (China, 20; Japan, 3; Korea, 18) | 3.0 | 51.5 | 10.6 | 17.0 | 6.0 | 10.6 | |||
| East Asia (19; n = 66) (Taiwan, 20) | 5.0 | 40.0 | 10.0 | 15.0 | 20.0 | ||||
| Latvia (22; n = 34) | 41.2 | 20.6 | 32.0 | ||||||
| Turkey (4; n = 41) | 4.8 | 56.1 | 19.5 | 4.9 | 7.2 | 2.4 | 2.4 | ||
| China (28; n = 86) | 2.0 | 41.0 | 40.0 | 3.0 | 4.0 | 2.0 | 2.0 | 10.0 | |
| Kaohsiung, Taiwan (9; n = 63) | 7.5 | 41.5 | 18.9 | 1.9 | 15.1 | 6.3 | 15.9 | ||
| Taiwan (this research) (n = 162) | 3.7 | 49.4 | 20.4 | 2.4 | 8.6 | 4.9 | 0.0 | 0.6 | 9.9 |
a
Studies on RMP drug-resistant strains isolated in Taiwan as to the multimutation frequency of the rpoB gene are indicated with boldface characters.