Table 2.
Summary of actions of adipokines depends on the cancer type.
| Cancer Type | Adipokine | Actions |
|---|---|---|
| Esophageal adenocarcinoma | Leptin ↑ | Correlates with lymph node involvement and tumor stage |
| Adiponectin ↓ | Low expressions compared to healthy control group | |
| Gastric cancer | Leptin ↑ | Ob-R expression is associated with poor prognoses and increases the expression of matrix metalloproteinases, which degrade ECM components |
| Adiponectin ↓ | Low expression is associated with an increased risk for gastric cancer | |
| Colorectal cancer | Leptin ↑ | Lymph node involvement, microvascular invasion, and advanced tumor stage |
| Resistin ↑ | Overexpression in a human colon cancer cell line | |
| Adiponectin ↓ | Suppression of colon cancer cells by its receptor-mediated AMPK activity | |
| Gynecologic cancer | Leptin ↑ | Promote cell migration and invasion in various in vitro studies on ovarian cancer |
| Adiponectin ↓ | Inversely associated with endometrial cancer | |
| Breast cancer | Leptin ↑ | Associated with tumor size, lymph node involvement, and metastasis |
| Visfatin ↑ | Associated with poor prognoses | |
| Resistin ↑ | Elevated expressions in breast cancer | |
| Apelin ↑ | Parameters including tumor size, stage, histological type, lymph node metastasis, and adverse prognoses | |
| Chemerin ↑ | Elevated expressions in breast cancer | |
| Omentin-1 ↓ | Low level in postmenopausal breast cancer |