Red ginseng supplementation for 4 weeks expresses the possibility of being a senolytic in aged mice. The 19-month-old male C57BL/6 mice were orally administered distilled water (Control, n = 6) or 300 mg/kg of aqueous RG extract (RG, n = 6) for 4 weeks. (A) Body weight (g) and (B) accumulated food intake (g) were monitored every 4 days. (C) 6 h fasted blood glucose levels (mg/dL) on weeks 0 and 4. (D) 16 h fasted blood glucose levels (mg/dL) on week 4. (E) Glucose tolerance test (GTT; 2 g/kg) on week 4 and the calculation of area under the curve (AUC). (F) Insulin tolerance test (ITT; 1 IU/kg) on week 4 and AUC. The GTT and ITT were conducted at three-day intervals. Ordinary two-way ANOVA was used to analyze body weights, food intakes, GTT, and ITT, followed by Student’s t-tests for blood glucose levels and AUC. The results are expressed as mean ± SEM. (** p < 0.01).