Red ginseng intake for 14 weeks maintains insulin homeostasis in aged mice. 19-month-old male C57BL/6 mice were fed ad libitum with a normal chow diet (Control; n = 10) or 0.4% (w/w) RG (RG, n = 10) for 14 weeks. (A) Body weight (g) and (B) accumulated food intake (g) was assessed every two weeks. (C) 6 h fasted blood glucose levels (mg/dL) on weeks 0 and 7. (D) Glucose tolerance test (GTT; 2 g/kg) on week 8 and the calculation of area under the curve (AUC). (E) Insulin tolerance test (ITT; 0.5 IU/kg) on week 7 and the calculation of AUC. Ordinary two-way ANOVA was used to analyze body weights, food intake, GTT, and ITT. Student’s t-test was used to analyze blood glucose levels and AUC. All results are expressed as mean ± SEM. (* p < 0.05, *** p < 0.005, **** p < 0.001).