Table 1.
Characteristics and concentrations of urine p75NTR/Crea from the acute brain injury cohort (n = 46) and healthy individuals using a modified Rankin Scale (mRS). Favorable mRS 0–3; unfavorable mRS 4–6.
| Variables | Favorable (n = 30) | Unfavorable (n = 16) | p-Value |
|---|---|---|---|
| Age in years | 0.7283 | ||
| Mean ± SD | 57.3 ± 13.3 | 58.8 ± 13.7 | |
| Min–Max | 23.0–75.0 | 34.0–74.0 | |
| Median (IQR) | 60.0 (48.0–68.0) | 65.0 (45.0–70.0) | |
| Sex | 0.9783 | ||
| Male | 17 (56.7) | 9 (56.3) | |
| Female | 13 (43.3) | 7 (43.8) | |
| Type of brain injury | 0.0373 | ||
| aSAH | 13 (43.3) | 9 (56.3) | |
| TBI | 3 (10.0) | 5 (31.3) | |
| IS | 14 (46.7) | 2 (12.5) | |
| p75NTR/Crea Early (ng/mg) | 0.3537 | ||
| Mean ± SD | 50.86 ± 36.10 | 40.49 ± 28.83 | |
| Min–Max | 1.3–156.4 | 8.7–107.3 | |
| Median (IQR) | 47.65 (21.3–73.2) | 33.80 (19.2–54.8) | |
| p75NTR/Crea Late (ng/mg) | 0.0325 | ||
| Mean ± SD | 42.79 ± 29.24 | 65.85 ± 35.04 | |
| Min–Max | 8.3–134.7 | 5.6–131.2 | |
| Median (IQR) | 33.84 (23.4–50.0) | 66.40 (38.5–96.4) | |
| p75NTR/Crea Healthy (ng/mg) | Healthy (n = 4) | <0.0001 † | |
| Mean ± SD | 0.542 ± 0.440 0.084–1.124 0.479 (0.155–0.991) |
||
| Min–Max | |||
| Median (IQR) | |||
| Age in years | >0.05 ‡ | ||
| Mean ± SD | 44.00 ± 16.95 | ||
| Min–Max | 33.0–69.0 | ||
| Median (IQR) | 37.0 (33.3–62.8) | ||
| Sex | >0.05 ‡ | ||
| Male | 2 (50.0) | ||
| Female | 2 (50.0) | ||
† Statistical comparisons of p75NTR/Crea between healthy versus favorable, and healthy versus unfavorable outcome groups (both comparisons p < 0.0001). ‡ Statistical comparisons of age and sex between healthy versus favorable, and healthy versus unfavorable outcome groups (both comparisons p > 0.05).