Table 4.
Notch signaling and intracellular trafficking in Drosophila Notch (N) EGFr cysteine-altering alleles.
| N Allele | Mutation (EGFr) | Bristle Formation 1 | Lateral Inhibition 2 | Inductive Signaling 3 | Intracellular Trafficking (Localization) |
|---|---|---|---|---|---|
| NX | p.Cys343Ser (EGFr 8) | Absent | Neurogenic | Depletion | Abnormal (loss of expression) |
| NOmicron | p.Cys343Tyr (EGFr 8) | Absent | Neurogenic | Depletion | Abnormal (ER 4) |
| NGamma | p.Cys398Tyr (EGFr 9) | Absent | Neurogenic | Depletion | Abnormal (ER) |
| NS | p.Cys407Ser (EGFr 9) | Absent | Neurogenic | Depletion | Abnormal (ER) |
| NIota | p.Cys413Ser (EGFr 10) | Absent | Neurogenic | Depletion | Abnormal (ER) |
| NG | p.Cys535Ser (EGFr 13) | Absent | Brain deformation | Depletion | Normal |
| NZeta | p.Cys993Ser (EGFr 25) | Absent | Neurogenic | Depletion | Abnormal (ER) |
| NH | p.Cys1155Ser (EGFr 29) | Absent | Normal | Normal | Abnormal (Early endosomes) |
| NJ | p.Cys1341Tyr (EGFr 34) | Absent | Normal | Normal | Normal |
Modified from Nurmahdi et al., 2022 [116]. 1 Defects of bristle formation reflect defects in lateral. inhibition and asymmetric cell division. 2 Defects of lateral inhibition in the embryonic central nervous system are neurogenic. Brain deformation reflects region-specific impairment of lateral inhibition. 3 Inductive signaling was evaluated by boundary cell formation in the embryonic hindgut. 4 ER: endoplasmic reticulum.