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. 2024 Jan 17;12(1):208. doi: 10.3390/biomedicines12010208

Figure 3.

Figure 3

Proteins expressed in the cell can pump antileukemic agents into the extracellular medium. 1—Binding of GO to CD33 on the cell surface. 2—Internalization of CD33/GO Complex into endosome. 3a—EC5/5OCS3-mediated degradation of CD33 via 26S proteasome. 3b—Recycling of GO/CD33 complex to cell surface. 3c—Hydrolytic release of calicheamicin in lysosome. 4—Diffusion of calicheamicin into cytoplasm. 5a—Translocation of calicheamicin into nucleus. 5b—Extrusion of calicheamicin via ABC transporters.