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This illustration showcases the sequence of events for activation of the NLRP3 inflammasome pathway. The cascade is triggered through the binding of microbial molecules (pathogen-associated molecular patterns, PAMPSs) to the TLR receptor. NLRP3 inflammasome can also be activated through crystalline substances (uric acid and calcium pyrophosphate dihydrate). This figure was created with BioRender.com.
