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. 2023 Sep 21;20(2):416–436. doi: 10.1080/15548627.2023.2259216

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 8. — Metformin attenuates crizotinib-induced cardiac complications in vivo. C57BL/6J mice (n = 10) were treated with vehicle, crizotinib (100 mg/kg), metformin (200 mg/kg) or metformin plus crizotinib for 6 weeks by means of intragastric administration. (A-C) the heart function of mice was measured by echocardiography. (D) serum was analyzed for CKMB level. n = 5. (E) H&E staining. Scale bar: 40 μm. (F) the cardiac remodeling gene expression relative to Actb in the indicated groups was shown. n ≥ 4. (G, H) Representative Sirius red and Masson-stained cardiac sections. Scale bar: 40 μm. (I) TEM observation of the left ventricle from C57BL/6J mice showed in (A). Representative images of the mitochondrial structure were shown on the left and enlarged views were presented on the right. Data were presented as mean ± SD. n = 3. The P value was calculated by one-way ANOVA with Sidak’s test (B to D and F). ****, P < 0.0001; ***, P < 0.001; **, P < 0.01; *, P < 0.05; ns, no significance. CTRL: control; Crizo: crizotinib.