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Protective effect of CAP18109–135 against the lethal toxicity of LPS/endotoxin in d-GalN-sensitized mice. (A) C3H/HeN mice were injected i.p. with CAP18109–135 at the indicated doses and immediately injected i.p. with LPS (100 ng/mouse) and d-GalN (18 mg/mouse). (B) C3H/HeN mice were injected i.p. with CAP18109–135 (40 μg/mouse) or saline, CAZ-endotoxin (100 or 200 ng of LPS equivalent/mouse) or saline, and d-GalN (18 mg/mouse). Death was scored for 1 week after the injection.
