TABLE 2.
Human peptides block LPS lethality in d-GalN-sensitized C57BL/6 micea
| Peptide | Amt of peptide (μg/mouse) | Amt of LPS (μg/mouse) | No. of mice that died/total no. | Survival (%) |
|---|---|---|---|---|
| None | 0.1 | 16/25 | 36.0 | |
| CAP18106–135 | 1.0 | 0.1 | 1/8 | 87.5b |
| CAP18109–135 | 0.1 | 0.1 | 5/10 | 50.0 |
| 1.0 | 0.1 | 5/18 | 72.2b | |
| CAP18114–135 | 0.1 | 0.1 | 7/10 | 30.0 |
| 1.0 | 0.1 | 9/19 | 52.6 | |
| CAP18109–132 | 1.0 | 0.1 | 7/8 | 12.5 |
a
LPS (1 μg/ml) was incubated with an equal volume of the indicated peptide (10 or 1 μg/ml) at 37°C for 30 min, and the mixture (0.2 ml) and d-GalN (20 mg/mouse) was sequentially injected i.p. into C57BL/6 mice.
b
P < 0.05 compared with the LPS control.