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. 2024 Jan 20;13(1):58. doi: 10.3390/biology13010058

Figure 6.

Figure 6

LRRK2 G2019S does not consistently affect regrowth of axons after axotomy. (A) Representative micrographs of TUBB3-stained GC1, Mut1, GC2, and Mut2 axons spanning the entire distal compartment (top) of separate MFCs. Conditions—no axotomy and 85 h post axotomy, with zoomed-in insets (bottom). Scale bar: 1000 µm, insets 100 µm. (B) Quantification of the area covered by axonal regrowth (raw data) at different times post axotomy in GC1 and Mut1 neurons (left) and GC2 and Mut2 neurons (right) (C) Quantification of % axonal regrowth of GC1 and Mut1 (left) and GC2 and Mut2 (right) neurons at different times post axotomy constrained between their respective no axotomy and 0.5 h controls. For all graphs: N = at least five independent experiments. Statistics were calculated using a 2-way ANOVA with Sidak’s multiple comparison test. **** corresponds to p-adj < 0.0001, * to p-adj < 0.05.