TABLE 1.
Comparison of clinical data at the time of HBeAg seroclearance between patients with and without precore and core promoter mutations
| Parameter | Value for groupa
|
|||||
|---|---|---|---|---|---|---|
| Core promoter
|
P value | Precore
|
P value | |||
| MT | WT | MT | WT | |||
| Age (yr) | 36.6 (15.3-80.5) | 30.3 (15.2-54.3) | 0.001 | 33.1 (15.2-69.8) | 36.1 (15.3-80.5) | 0.095 |
| Albumin (g/liter) | 46 (22-60) | 48 (36-53) | 0.008 | 47 (32-53) | 46 (22-60) | 0.50 |
| ALT (U/liter) | 38 (13-313) | 24 (6-393) | 0.012 | 29.0 (6-393) | 39 (13-313) | 0.086 |
| AST (U/liter) | 29 (11-218) | 25 (15-181) | 0.034 | 26 (15-218) | 29 (11-164) | 0.17 |
| Bilirubin (μmol/liter) | 10 (4-187) | 11 (4-59) | 0.87 | 11 (4-73) | 11 (4-187) | 0.79 |
| AFP (ng/liter) | 5 (1-1700) | 3 (1-32) | 0.007 | 4 (1-284) | 4 (1-1700) | 0.32 |
| HBV DNA levels by Digene assay (×106 copies/ml) | <0.14 (<0.14-442.14) | <0.14 (<0.14-279.89) | 0.99 | <0.14 (<0.14-329.87) | <0.14 (<0.14-442.14) | 0.69 |
a
Values are expressed as median (range). MT, mutant; WT, wild type.