TABLE 3.
Comparison of clinical data at the time of HBeAg seroclearance between patients with and without exacerbations after HBeAg seroclearance
| Parameter | Value in patientsa:
|
P value | |
|---|---|---|---|
| With acute exacerbation | Without acute exacerbation | ||
| Albumin (g/liter) | 47 (36-60) | 46 (22-53) | 0.17 |
| ALT (U/liter) | 44 (14-191) | 29 (6-393) | 0.002 |
| AST (U/liter) | 32.5 (20-101) | 27 (11-218) | <0.001 |
| Bilirubin (μmol/liter) | 12.5 (4-59) | 10 (4-187) | 0.003 |
| AFP (ng/liter) | 6.5 (1-178) | 4 (1-1700) | 0.003 |
| HBV DNA by Digene assay (106 copies/ml) | <0.14 (<0.14-442.14) | <0.14 (<0.14-329.87) | 0.16 |
| Precore mutations | 21/56 (37.5%) | 74/145 (51.0%) | 0.12 |
| Core promoter mutations | 48/56 (85.7%) | 93/145 (64.1%) | 0.003 |
a
Values are expressed as median (range).