TABLE 4.
Comparison of clinical data at the time of HBeAg seroclearance between patients with and without HBeAg seroreversion
| Parameter | Value for patientsa
|
P value | |
|---|---|---|---|
| With HBeAg seroreversion | Without HBeAg seroreversion | ||
| Age (yr) | 40.2 (28.6-55.7) | 34.2 (15.2-80.5) | 0.013 |
| Albumin (g/liter) | 47 (36-53) | 47 (22-60) | 0.47 |
| ALT (U/liter) | 57 (14-155) | 33 (6-393) | 0.005 |
| AST (U/liter) | 42.5 (19-94) | 28 (11-218) | 0.004 |
| Bilirubin (μmol/liter) | 13.7 (6-45) | 10 (4-187) | 0.025 |
| AFP (ng/liter) | 9 (2-154) | 4 (1-1700) | 0.02 |
| HBV DNA by Digene assay (106 copies/ml) | 0.16 (<0.14-5.52) | <0.14 (<0.14-442.1) | 0.15 |
| Precore mutations | 3/14 (21.4%) | 92/187 (49.2%) | 0.054 |
| Core promoter mutations | 11/14 (78.6%) | 130/187 (69.5%) | 0.56 |
a
Continuous values are expressed as median (range).