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. 2023 Dec 30;14(1):53. doi: 10.3390/biom14010053

Figure 7.

Figure 7

IP3 receptor blocker 2-APB enhances CaT alternans. (A): Traces of CaTs (top) and CaT ARs recorded over time in control and in presence of 2-APB (5 µM). (B): Mean ± SEM and individual CaT ARs observed in control, in 2-APB and after washout of 2-APB (N/n = 4/10, Tukey’s test). (C): Mean ± SEM and individual CaT amplitudes (a) and diastolic [Ca2+]i (b) observed in control and in the presence of 2-APB recorded at 0.5 Hz pacing in the absence of alternans (N/n = 3/12, paired t-test). (D): Application of 2-APB in the presence of Ang II further increases CaT AR (N/n = 2/7; Tukey’s test). (E): Mean ± SEM and individual CaT ARs recorded in control and after application of TRPC6/3 channel blocker GSK2833503A (GSK; 200 nM) and simultaneous application of GSK and 2-APB (N/n = 4/7; Tukey’s test).