Figure 3.

SMAD4 and YAP cooperate to induce ADM associated transcriptional changes. (A) Heatmap showing binding of SMAD4 and YAP1 at SMAD4 ChIP peaks in AD cells. (B) Motif analysis of SMAD4 ChIP Peaks in AD cells. (C) Venn diagram showing overlap of YAP1 bound genes and SMAD4 bound genes in AD cells. (D) IGV tracks showing YAP1 and SMAD4 binding at the loci of ADM associated genes. (E) Venn diagram showing overlap between AD induced or repressed genes and genes co-bound by YAP1 and SMAD4. (F) Gene ontology of genes which are upregulated in AD cells and co-bound by YAP1 and SMAD4. (G) Expression heatmap of ADM-induced, cytokine-associated genes in AD cells and fresh acinar cells. Gene symbols in red are co-bound by YAP1 and SMAD4.