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YAP1/TAZ overexpression induces acinar cell proliferation, and TGFβ inhibitor blocks YAP1/TAZ-induced proliferation. (A) Schematic of experiment strategies. (B) Representative images of sphere formation of acinar cells transfected with vector-mCherry or YAP1/TAZ-mCherry, and treated with or without SB431542, on Day 7 and Day 14. Scale bar, 100 µm. (C) Quantification results of sphere formation on Day 7 and Day 14. N = 4–6. Error bars = S.E.M. * p < 0.05, *** p < 0.001.
