Figure 2.

Effect of the flavonoid rutin on the regulation of miRNA-125b in GL15 human GBM cells. miRNA analyses using RT-qPCR. GL15 cells were treated for 24 h with rutin at 30 µM (R30) or maintained under control conditions (0.03% DMSO). The expression of intracellular miRNA-125b and the extracellular matrix (secretome) were analyzed. Values were expressed as means ± SD (n = 3); results expressed are relative to control and treatment; significance was determined by an unpaired t-test; ** p < 0.002; * p < 0.02.