Table 1.
Common autoantibodies and their association with autoimmune liver disease.
| Antibody | Common Association | Other Associations | Method of Detection |
|---|---|---|---|
| ANA | AIH type1 | AIC, PSC, PBC # | IIF |
| ASMA | AIH type1 | AIC, PSC, PBC | IIF, IB, ELISA |
| LKM-1 | AIH type2 | HCV | IIF, IB, ELISA |
| AMA | PBC | Rare- AIH type 1 (low titers) | IIF, IB, ELISA |
| SLA/LP | AIH | - | IB, ELISA |
| PANCA | PSC | AIH, PSC | IIF, ELISA |
| LKM3 | AIH type2 | - | IIF, IB, ELISA |
| LC1 | AIH type2 | HCV | IIF, IB, ELISA |
AIH—autoimmune hepatitis, ANA—antinuclear antibodies, ASMA—anti smooth muscle actin, LKM—liver kidney muscle; SLA/LP—soluble liver antigen/liver pancreas, PANCA—perinuclear anti neutrophil cytoplasmic antibodies; LC—liver cytosol, ELISA—enzyme linked immunosorbent assay, IIF—indirect immunofluorescence; IB—immunoblotting, PBC—primary biliary cholangitis, PSC—primary sclerosing cholangitis, AIC—autoimmune cholangitis, HCV—hepatitis C virus; # In ANA positive cases of PBC–sp100/gp210 may be detected by IB [4].