Table 2.
Histologic features in the scoring system for diagnosis of autoimmune hepatitis.
| 1993 Johnson et al. [19] | 1999 Alvarez et al. [20] | ||
|---|---|---|---|
| Chronic active hepatitis with lobular involvement, piecemeal necrosis, and bridging necrosis | +3 | Interface hepatitis | +3 |
| Chronic active hepatitis with piecemeal necrosis without lobular involvement and bridging necrosis | +2 | Plasma cells | +1 |
| Rosetting of liver cells | +1 | Rosettes | 1 |
| Infiltrated with plasma cell predominance | +1 | None of the above | −5 |
| Biliary changes | −1 | Biliary changes * | −3 |
| Any other changes (e.g., granulomas, siderosis and copper deposits) indicative of a different etiology | −3 | Other features | −3 |
* ‘Biliary changes’ refers to bile duct changes typical of PBC or PSC (i.e., granulomatous cholangitis, or severe concentric periductal fibrosis, with ductopenia) and/or a substantial periportal ductular reaction (so-called marginal bile duct proliferation with a cholangiolitis) with copper/copper-associated protein accumulation.