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. 2024 Jan 19;16(2):432. doi: 10.3390/cancers16020432

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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GLI-1-amplified neoplasm with CDK4 coamplification. (A) Round and epithelioid cell neoplasm with isolated mitoses and low-grade morphology. Hematoxylin and eosin (H and E) 400×, (B) GLI1 immunoreactivity with moderade and nuclear expression 200×. (C) CDK4 moderates and diffuses nuclear immunoreactivity 400×. (D) Strong and diffuse p16 immunoexpression in GLI1 with nuclear and cytoplasmic stain, 200×, (E,F) GLI1 (red signals/GLI1 and green signals centromeric region) and CDK4 (red signals/CDK4, green signals centromeric region, yellow signals/signal overlaps/green and red) coamplification by FISH. Magnification 63×.