High-protein diet (HPD) enhances AF susceptibility via AIM2 inflammasome. (A) Representative recordings of lead-2 surface ECG and intracardiac electrograms in WT and Aim2−/− mice after 4 weeks’ feeding of NC or HPD, respectively. Red arrows indicate the end of the burst pacing protocol. ‘P’ and ‘R’ designate the P-wave and QRS complex on surface ECG, while ‘A’ and ‘V’ represent the atrial excitation and ventricular excitation on intracardiac electrograms, respectively. (B) The incidence of pacing-induced reproducible AF. (C) The duration of pacing-induced AF. * p < 0.05, ** p < 0.01. p-values determined by Fisher’s exact test in (B), and Kruskal–Wallis with Dunn’s multiple comparisons test in (C).