Table 3.
Echocardiographic variables of left ventricular diastolic function pre- and post-trazodone in 12 healthy cats
| Variable | Pre-trazodone | Post-trazodone | P value |
|---|---|---|---|
| E (m/s) | 0.69 ± 0.14 | 0.66 ± 0.14 | 0.447 |
| A (m/s) | 0.53 ± 0.09 | 0.47 ± 0.12 | 0.068 |
| E:A | 1.32 ± 0.25 | 1.47 ± 0.31 | 0.046* |
| DTE (m/s) | 79.0 ± 14.0 | 74.5 ± 13.9 | 0.247 |
| DTE slope (m/s2) | 9.3 ± 2.6 | 9.3 ± 3.5 | 0.962 |
| E’ (m/s) | 0.08 ± 0.02 | 0.09 ± 0.01 | 0.199 |
| A’ (m/s) | 0.05 ± 0.01 | 0.49 ± 0.01 | 0.221 |
| IVRT (ms) | 51.5 ± 7.0 | 52.8 ± 6.5 | 0.655 |
| PVS (m/s) | 0.51 ± 0.10 | 0.51 ± 0.13 | 0.788 |
| PVD (m/s) | 0.41 ± 0.08 | 0.43 ± 0.09 | 0.318 |
| PVA (m/s) | 0.23 ± 0.04 | 0.28 ± 0.07 | 0.019* |
| PVAdur (ms) | 53.4 ± 6.4 | 50.5 ± 9.4 | 0.287 |
Data are mean ± SD
Difference between pre- and post-trazodone was statistically significant
E = peak velocity of early diastolic transmitral flow; A = peak velocity of late diastolic transmitral flow; E:A = ratio between E and A; DTE = deceleration time of early diastolic transmitral flow; DTE slope = slope of DTE; E’ = peak early diastolic velocity of lateral mitral annulus; A’ = peak late diastolic velocity of lateral mitral annulus; IVRT = isovolumetric relaxation time; PVS = peak velocity of pulmonary vein systolic flow; PVD = peak velocity of pulmonary vein diastolic flow; PVA = peak velocity of pulmonary vein atrial reversal flow; PVAdur = duration of the PVA