Table 2.

Multivariable analyses.

Factor	Hazard Ratio (95% CI)	p-Value
RFS-Combined cohort
31-GEP
Class 1A	Reference	--
Class 1B/2A	2.63 (1.43–4.83)	0.002
Class 2B	5.16 (2.54–10.47)	<0.001
AJCC
Stage IA	Reference	--
Stage IB	2.98 (1.64–5.40)	<0.001
MSS-Combined cohort
31-GEP
Class 1A	Reference	--
Class 1B/2A	2.35 (0.60–9.29)	0.223
Class 2B	11.08 (3.10–39.63)	<0.001
AJCC
Stage IA	Reference	--
Stage IB	3.00 (0.87–10.37)	0.082
MSS-SEER cohort
31-GEP
Class 1A	Reference	--
Class 1B/2A	1.37 (0.50–3.71)	0.542
Class 2B	9.23 (4.23–20.18)	<0.001
AJCC
Stage IA	Reference	--
Stage IB	0.82 (0.39–1.74)	0.609