Figure 1.

Schema of a typical external beam radiotherapy (EBRT) course using conventional fractionation in gynecologic malignancies with 25 fractions delivered daily over 5 weeks (top, in black). This fractionation is typically seen in radical EBRT treatments of locally advanced cervical cancers or in the adjuvant setting of endometrial cancer, post-hysterectomy. The role of a moderately hypofractionated course with 15 daily fractions is under investigation in randomized phase 2 trials involving cervical cancer patients (middle, in blue). The role of ultrafractionated regimes with five fractions delivered every other day is currently being investigated in a phase 2 randomized trial in the adjuvant endometrial cancer setting (bottom, in green).