Table 1.

Dual roles of Sirt1 and Sirt6: modulating tumorigenesis and anti-tumorigenic pathways.

Name	Function	Mechanism	References
Sirt1	Pro-tumorigenic	Yap signaling pathway	[11,12]
		Modulation of angiogenesis via FOXO1	[13]
		Deacetylation of histone substrates, transcription factors, and cofactors	[14]
		FOXO1 and YAP signaling pathway modulated by USP22	[15]
		Regulating autophagy through the deacetylation of ATGs	[16]
		Targeting p53 to suppress ferroptosis	[17]
		Mediated by candidate oncogene circNOP10	[18]
		FoxO1-Rab7–autophagy axis	[19]
		Deacetylation of Beclin-1 and other autophagy mediators	[20]
		Inhibiting PI3K/AKT pathway	[21]
		Sirt1 downregulation by MiR-204	[22]
		By the results of DBC1, H4K16Ac, and H3K9Ac	[23]
		Sirt1 transactivation by ATF4	[24]
		Nampt/sirt1/c-myc positive feedback loop	[25]
	Anti-tumorigenic	Sirt1 targeted by micro-RNAs (miR-543, miR-132-3p/miR-212-3p, miRNA-12129, miR-1301-3p, Has-miR-34a-5p, miR-132, miR-543, miR-183)	[15,26,27,28,29,30,31,32]
		Regulating ARHGAP5 expression	[33]
		Initiating an AMPK/FOXO3 positive feedback loop	[34]
		Via STAT3/MMP-12 signaling	[35]
		G1-phase arrest via NF-κB/Cyclin D1 signaling	[19]
		Repression of activation of STAT3 and NF-κB proteins via deacetylation	[36]
		Inducing G1 phase arrest and senescence by resveratrol	[37]
Sirt6	Anti-tumorigenic	Inhibition of JAK2/STAT3 pathway	[38]
		Promoting ferroptosis	[39]