Figure 2.

Gene alterations enriched in primary vs. metastatic BRAF mutant tumors. Gene alterations present in melanoma (A–C), CRC (D–F), and NSCLC (G–I) based on percent of samples with the gene alteration in primary (y-axis) or metastatic (x-axis) tumors. Genes that were present in a minimum of 1 primary and metastatic tumor are included. Pearson Correlation (R) was calculated for each panel. Colored dots represent significant enrichment (p < 0.05) in primary (blue) or metastatic (red) tumors (p value derived from two-sided Fisher Exact test).