Table 2.
Multivariable analyses of factors associated with non-V600 BRAF mutations (Class 2/3/Fusion) vs. V600 BRAF mutations (Class 1) OR = odds ratio; CI = Confidence Interval.
| Univariable | Multivariable | |||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p Value | OR | 95% CI | p Value | |
| Gender | ||||||
| Male vs. Female | 1.33 | 1.19–1.50 | <0.0001 | 1.55 | 1.35–1.76 | <0.0001 |
| Age | ||||||
| ≥60 vs. <60 | 1.44 | 1.28–1.62 | <0.0001 | 1.28 | 1.12–1.46 | <0.0001 |
| Primary Race | ||||||
| Black vs. other | 2.00 | 1.50–2.67 | <0.0001 | 1.58 | 1.13–2.20 | 0.007 |
| Primary tumour type | ||||||
| Melanoma | 0.54 | 0.48–0.62 | <0.0001 | 0.50 | 0.43–0.59 | <0.0001 |
| Colorectal | 0.42 | 0.36–0.50 | <0.0001 | 0.38 | 0.31–0.46 | <0.0001 |
| NSCLC | 4.89 | 4.13–5.79 | <0.0001 | 3.08 | 2.53–3.75 | <0.0001 |
| Sample Type | ||||||
| Metastatic vs. primary | 0.97 | 0.86–1.10 | 0.699 | - | - | - |
| Genomic co-mutations | ||||||
| RAS mt vs. wild-type | 18.4 | 13.37–25.34 | <0.0001 | 19.18 | 13.80–26.64 | <0.0001 |
| Variant Allele Frequency | ||||||
| ≥26% vs. <26% | 0.68 | 0.61–0.78 | <0.0001 | - | - | - |