Skip to main content
. 2024 Jan 11;13(2):134. doi: 10.3390/cells13020134

Figure 2.

Figure 2

Current strategies to prevent GvHD and GvL include (a) the depletion of αβ T and CD19+ B cells from mobilized peripheral blood stem cells produces the generation of an allogeneic graft enriched for CD34+ stem cells and γδ T lymphocytes, preserving the NK compartment; (b) the depletion of I T cells (CD45RA+) is depicted; (c) purified Tregs are separated and infused together with CD34+ hematopoietic stem cells, as well as with conventional T cells; (d) NK cells are selected and infuI; (e) the suicide gene therapy using the herpes simplex thymidine kinase (HSV-TK) gene is represented. The HSV-TK gene is involved in the metabolism of antiviral ganciclovir and causes the selective death of transfected cells when exposed to ganciclovir.